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KMID : 1189220080350010069
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Korean Journal of Reproductive Medicine
2008 Volume.35 No. 1 p.69 ~ p.76
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Relationship between FSH Receptor Genotype and Clinical Outcomes of IVF-ET in Infertile Korean Women
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Moon Mi-Hye
Choi Hye-Won
Kim Min-Gi
Lee Hyoung-Song
Cha Sun-Hwa
Song In-Ok
Koong Mi-Kyoung
Jeon Jin-Hyun
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Abstract
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Objective: The purposes of this study were to determine the distribution of follicle-stimulating hormone receptor (FSHR) genotypes in infertile Korean women and to evaluate the relationship between FSHR genotypes and clinical outcomes of IVF-ET cycles.
Methods: Genomic DNA was extracted from peripheral blood in 1,020 of infertile Korean women. Genotypes of FSHR at Thr307Ala (T/A) and Asn680Ser (N/S) were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Clinical outcomes related to the genotypes of FSHR were evaluated in IVF-ET cycles (n=302) with controlled ovarian hyperstimulation (COH) of infertile women under 40 years old.
Results: In a population of 1,020 infertile Korean women, the frequency of TT/NN, TA/NS and AA/SS for the major variant Thr307Ala and Asn680Ser was 44.80%, 41.96% and 10.49%, respectively. There was no significant difference in characteristics of ovarian response and clinical pregnancy rate among the major genotypes of FSHR in IVF-ET cycles with COH. However, implantation rate of AA/SS patients was significantly higher than that of TT/NN patients (24.5% vs 15.7%, p<0.05).
Conclusion: This study showed that FSHR genotype was not directly associated with ovarian response in IVF-ET cycles with COH. The relationship between clinical outcomes and FSHR genotypes of patients should be substantiated by further studies.
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KEYWORD
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Follicle-stimulating hormone receptor (FSHR), Genotype, Controlled ovarian hyperstimulation (COH), Ovarian response, Clinical outcomes
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